HOW MUCH YOU NEED TO EXPECT YOU'LL PAY FOR A GOOD LSD CRYSTAL

While in the LSD-bound crystal structure, the aspect chain from the lid residue L209EL2 kinds intensive hydrophobic contacts with the two LSD and surrounding residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to expose the binding pocket in simulation, many of those contacts broke. We Therefore hypothesized that L209EL2 acts like